Metabolic adaptation and oxaloacetate homeostasis inP. fluorescensexposed to aluminum toxicity
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منابع مشابه
Metabolic adaptation and oxaloacetate homeostasis in P. fluorescens exposed to aluminum toxicity.
Microbial systems are known to elaborate intricate metabolic strategies in an effort to fend the toxic impact of numerous metals. In this study, we show that the exposure of Pseudomonas fluorescens to aluminum (Al) resulted in a metabolic shift aimed at diverting oxaloacetate towards the biogenesis of an aluminophore. This metabolic alteration was characterized by uncoupling of two gluconeogeni...
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Iron (Fe) is a critical element in all aerobic organisms as it participates in a variety of metabolic networks. In this study, aluminum (Al) and gallium (Ga), two Fe mimetics, severely impeded the ability of the soil microbe Pseudomonas fluorescens to perform oxidative phosphorylation. This was achieved by disrupting the activity and expression of complexes I, II, and IV. These toxic metals als...
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Aluminum toxicity in patients with chronic renal failure has been related to renal osteodystrophy and dialysis encephalopathy (DES). The toxicity is associated with renal osteodystrophy in two ways. One association is the iatrogenic effect of excessive use of aluminum hydroxide gels resulting in hypophosphatemia which interferes with bone mineralization. The second association may involve depos...
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ژورنال
عنوان ژورنال: Journal of Basic Microbiology
سال: 2008
ISSN: 0233-111X,1521-4028
DOI: 10.1002/jobm.200800007